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ROSLINCT and REPROCELL awarded £1.2 million project from Innovate UK for clinical-grade stem cell production

Funding will be used to improve the efficiency of induced pluripotent stem cell production. 

Edinburgh, UK and Glasgow, UK: ROSLINCT, a leading cell and gene therapy contract manufacturing organisation, today announced it is to receive investment to collaborate with REPROCELL Europe Ltd (REPROCELL), a UK-based stem cell company, on a £1.2million project which will develop a faster, more cost-effective method of producing clinical-grade induced pluripotent stem cells (iPSCs). The investment comes from Innovate UK’s Medicines Manufacturing Round 2 competition, as part of the UK Government investment strategy in developing technology to transform health and social care.

To date, most research into iPSCs, which are considered one of the most promising seed cell sources in regenerative medicine, has been early stage. A major challenge is the production of iPSCs suitable for clinical use. With this investment, ROSLINCT and REPROCELL will develop an innovative strategy for the production of clinical iPSCs, by using a novel, safe RNA-based reprogramming method. This will enable quicker and safer generation of cells for both allogeneic and autologous therapies and provide scope for commercialisation and licensing of the generated cell lines to the biotechnology sector.

The iPSCs will provide a suitable starting material for a number of advanced therapy medicinal products (ATMPs) that offer ground breaking opportunities for the treatment of life-changing and life-threatening disease and injury, including those where patient’s needs are currently unmet.

Bringing together the expertise of ROSLINCT and REPROCELL will provide a step change in the production of clinical grade iPSCs and centre the know-how and manufacturing within the UK.

Janet Downie, CEO of ROSLINCT, said: This investment provides a fantastic opportunity to combine the expertise of ROSLINCT and REPROCELL, enabling two Scottish SMEs to devlop a competitive and disruptive impact on the supply of clinical iPSCs, therefore accelerating the development of potentially life changing therapies.”

Dr David Bunton, CEO of REPROCELL commented: “The creation of therapeutic stem cells using RNA is the safest and fastest method available. When combined with the automation and manufacturing capabilities of ROSLINCT, we aim to make it easy for companies with new therapies to rapidly and cost-efficiently enter clinical trials and then scale-up for commercial manufacturing.”

For further information please visit: www.roslinct.com

Collaboration in the life sciences sector in Scotland is paramount for success and overall contributes to achieving the ‘2025 vision’ of reaching £8bn turnover. Find out who you could collaborate with me here. 

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